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Effect of piperine on pentobarbitone induced hypnosis in rats.

Mujumdar, A M; Dhuley, J N; Deshmukh, V K; Raman, P H; Thorat, S L; Naik, S R.

Indian J Exp Biol ; 1990 May; 28(5): 486-7

Article in English | IMSEAR | ID: sea-57642

ABSTRACT

Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time. It is possible that, piperine inhibits liver microsomal enzyme system and thereby potentiates the pentobarbitone sleeping time.

Subject(s)

Alkaloids , Animals , Benzodioxoles , Drug Synergism , Hypnotics and Sedatives , Male , Microsomes, Liver/drug effects , Pentobarbital/administration & dosage , Piperidines/administration & dosage , Polyunsaturated Alkamides , Rats , Sleep/drug effects

Anti-inflammatory activity of 6MFA, a microbial product of fungal origin.

Naik, S R; Deshmukh, V K; Thorat, S L; Raman, P H.

Hindustan Antibiot Bull ; 1984 Aug-Nov; 26(3-4): 138-9

Article in English | IMSEAR | ID: sea-2274

Subject(s)

Animals , Anti-Inflammatory Agents/pharmacology , Antiviral Agents/pharmacology , Fungal Proteins/pharmacology , Rats

Some pharmacological and toxicological effects of JA-20, a new polyene macrolide.

Naik, S R; Jalit, R N; Raman, P H; Karnick, A K; Gopalkrishnan, K S; Nalini, I; Thorat, S L.

Hindustan Antibiot Bull ; 1981 ; 23(): 6-11

Article in English | IMSEAR | ID: sea-2631

Subject(s)

Animals , Anti-Bacterial Agents/pharmacology , Cats , Female , Guinea Pigs , Macrolides , Male , Mice , Muscle Contraction/drug effects , Polyenes/pharmacology , Rats

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